Recent progress in materials development of denture tissue conditioner-A systematic review

Abstract

Denture tissue conditioners play essential role in treating damaged oral mucosa, improving the comfort of patients, and providing effective adaptation of prostheses. Innovations in materials science over the past few decades have produced better formulations that have improved mechanical, antibacterial, and physical properties. This systematic review aims to assess and summarize the most recent data on improvements in denture tissue conditioners, emphasizing on material improvements, clinical performance, and antimicrobial efficiency. A complete literature search was undertaken using electronic databases such as PubMed, science direct, Cochrane and Medline, with publications published between 2011 and 2025. Predetermined exclusion and inclusion criteria were used to select papers, with a focus on randomized controlled trials, in vitro, and in vivo studies on newer experimental tissue conditioner materials. Data has been gathered and evaluated for bias. In total, 41 studies fulfilled the inclusion criteria. Major advances include the addition of antibacterial agents (such as silver nanoparticles, essential oils and fluorescent carbon), improved mechanical properties and increased conditioner longevity. Numerous studies found considerable reductions in microbial colonization while maintaining integrity of material. Modifications made with organic compounds and biocompatible resins have also showed promise in terms of mucosal healing and clinical results. The clinical performance and therapeutic capacity of denture tissue conditioners have been significantly improved by recent advances. Yet, to confirm these results and encourage broad clinical adoption, further extensive long-term clinical investigations are required. Future studies should concentrate on maximizing the harmony of antibacterial efficacy, patient comfort, and material performance.